Biological Physics
Supramolecular Structures Lab
Lösche/Heinrich Group
Mathias Lösche
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Contact412-268-2735, Want to chat by e-mail w/o being overheard? |
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Education
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| 1976 – 83 | Undergraduate School in Physics (Ulm Univ., Germany), M.S. 1983 |
| 1983 – 86 | Graduate Program in Biophysics (TU Munich, Germany), Ph.D. 1986 |
| 1986 – 88 | Postdoctoral Researcher in Biophysics (UC San Diego, CA) |
| 1988 – 94 | Asst. Professor in Phys. Chem. (Univ. Mainz, Germany), Habilitation 1994 |
| 1995 | Professorship (tenure) in Exp. Physics (Leipzig University, Germany) |
Professional Appointments
| 2008 – | Professor of Biomedical Engineering (by courtesy), Carnegie Mellon |
| 2005 – | Professor of Physics, Carnegie Mellon, Physics Dept., Pittsburgh, PA |
| 2002 – 06 | Director, CNBT Consortium, NIST Cntr. f. Neutr. Res., Gaithersburg, MD |
| 2002 – 05 | Res. Professor, Dept. of Biophysics, Johns Hopkins, Baltimore, MD |
| 1998 – 02 | Head, Biomembrane Physics Group, Leipzig University, Germany |
| 1994 – 05 | Assoc. Prof. of Physics, Exp. Phys., Leipzig University, Germany |
| 1988 – 94 | Assistant Professor in Physical Chemistry, Mainz University, Germany |
| 1986 – 88 | Post-doctoral research fellow, Biophysics Dept, UCSD, La Jolla, CA |
Recent Publications
H. Nanda, F. Heinrich, and M. Lösche, Membrane association of the PTEN tumor suppressor: Neutron scattering and MD simulations reveal the structure of protein-membrane complexes, Methods (2015), in press.
download accepted manuscript
A. Kalinowski, P. N. Yaron, Z. Qin, S. Shenoy, M. J. Buehler, M. Lösche, and K. N. Dahl, Interfacial binding and aggregation of lamin A tail domains associated with Hutchinson–Gilford progeria syndrome, Biophys. Chem. 195 (2014), 43 - 38.
R. Pulido, J. T. Barata, A. Carracedo, V. J. Sid, I. D. Chin-Sang, V. Davé, J. den Hertog, P. Devreotes, B. Eickholt, C. Eng, F. B. Furnari, M. M. Georgescu, A. Gericke, B. Hopkins, X. Jiang, S. R. Lee, M. Lösche, P. Malaney, X. Matias-Guiu, M. Molina, P. P. Pandolfi, R. Parsons, P. Pinton, C. Rivas, R. M. Rocha, M. S. Rodriguez, A. H. Ross, A. Serrano, V. Stambolic, B. Stiles, A. Suzuki, S. S. Tan, N. K. Tonks, L. C. Trotman, N. Wolff, R. Woscholski, H. Wu, and N. R. Leslie, A unified nomenclature and amino acid numbering for human PTEN, Sci. Signal. 7 (2014), pe15.
F. Heinrich and M. Lösche, Zooming in on disordered systems: Neutron reflection studies of proteins associated with fluid membranes, Biochim. Biophys. Acta 1838 (2014), 2341 - 2349.
F. Heinrich, H. Nanda, H. Z. Goh, C. Bachert, M. Lösche, and A. D. Linstedt, Myristoylation restricts orientation of the GRASP domain on membranes and promotes membrane tethering, J. Biol. Chem. 289 (2014), 9683 - 9691.
A. Gericke, N. R. Leslie, M. Lösche, and A. H. Ross, PI(4,5)P2-mediated cell signaling: Emerging principles and PTEN as a paradigm for regulatory mechanism, Ch. 6 in: Advances in Experimental Medicine and Biology, Vol. 991, Lipid-Mediated Membrane Targeting of Proteins, Ed.: D. G. S. Capelluto (Springer, New York, 2013), 85 - 104.
A. Kalinowski, Z. Qin, K. Coffey, R. Kodali, M. J. Buehler, M. Lösche, K. N. Dahl, Calcium causes a conformational change in lamin A tail domain that promotes farnesyl-mediated membrane association, Biophys. J. 104 (2013), 2246 - 2253.
R. Budvytyte, G. Valincius, G. Niaura, V. Voiciuk, M. Mickevicius, H. Chapman, H.-Z. Goh, P. Shekhar, F. Heinrich, S. Shenoy, M. Lösche, and D. J. Vanderah, Structure and properties of tethered bilayer lipid membranes with unsaturated anchor molecules, Langmuir 29 (2013), 8645 - 8656.
S. Shenoy, H. Nanda and M. Lösche, Membrane association of the PTEN tumor suppressor: Electrostatic interaction with phosphatidylserine-containing bilayers and regulatory role of the C-terminal tail, J. Struct. Biol. 180 (2012), 394 - 408.
Goh H. Z., C. Tan, M. Deserno, F. Lanni, and M. Lösche, Hemifusion of giant unilamellar vesicles with planar hydrophobic surfaces: A fluorescence microscopy study, Soft Matter 8 (2012), 10877 - 10886.
S. Shenoy, P. Shekhar, F. Heinrich, M.-C. Daou, A. Gericke, A. H. Ross, and M. Lösche, Membrane association of the PTEN tumor suppressor: Molecular details of the protein-membrane complex from SPR binding studies and neutron reflection, PLoS One 7 (2012), e32591.
M. I. Lioudyno, M. Broccio, Y. Sokolov, S. Rasool, J. Wu, M. T. Alkire, V. Liu, J. A. Kozak, P. R. Dennison, C. G. Glabe, M. Lösche, and J. E. Hall, Effect of synthetic Aβ peptide oligomers and fluorinated solvents on Kv1.3 channel properties and membrane conductance, PLoS One 7 (2012), e35090.
P. N. Yaron, B. D. Holt, P. A. Short, M. Lösche, M. F. Islam, and K. N. Dahl, Single wall carbon nanotubes enter cells by endocytosis and not membrane penetration, J. Nanobiotechn. 9 (2011), 45-1 - 15.
P. Shekhar, H. Nanda, M Lösche, and F. Heinrich, Continuous distribution model for the investigation of complex molecular architectures near interfaces with scattering techniques, J. Appl. Phys. 110 (2011), 102216-1 - 12.
H. Nanda, S. Datta, F. Heinrich, M. Lösche, J. E. Curtis, A. Rein, S. Krueger, Electrostatic interactions and binding orientation of HIV-1 matrix, studied by neutron reflectivity, Biophys. J. 99 (2010), 2516 - 2524.
/ download paper / download supplement
P. Cizas, R. Budvytyte, R. Morkuniene, R. Moldovan, M. Broccio, M. Lösche, G. Niaura, G. Valincius, and V. Borutaite, Size-dependent neurotoxicity of β-amyloid oligomers, Arch. Biochem. Biophys. 496 (2010), 84 - 92.
S. Shenoy, R. Moldovan, J. Fitzpatrick, D. J. Vanderah, M. Deserno, and M. Lösche, In-plane homogeneity and lipid dynamics in tethered Bilayer Lipid Membranes (tBLMs), Soft Matter 6 (2010), 1263 - 1274.
M. B. Smith, D. J. McGillivray, J. Genzer, M. Lösche, and P. K. Kilpatrick, Neutron reflectometry of peptide-incorporated suported hybrid bilayers, Soft Matter 5 (2010), 862 - 865.
S. A. Holt, A. P. Le Brun, C. F. Majkrzak, D. J. McGillivray, F. Heinrich, M. Lösche, and J. H. Lakey, An ion channel containing model membrane: Structural determination by magnetic contrast variation neutron reflectometry, Soft Matter 5 (2009), 2576 - 2586.
F. Heinrich, T. Ng, D. J. Vanderah, P. Shekhar, M. Mihailescu, H. Nanda, and M. Lösche, A new lipid anchor for sparsely-tethered bilayer lipid membranes, Langmuir 25 (2009), 4219 - 4229.
D. J. McGillivray, G. Valincius, F. Heinrich, J. W. F. Robertson, D. J. Vanderah, W. Febo-Ayala, I. Ignatjev, M. Lösche, and J. J. Kasianowicz, Structure of functional Staphylococcus aureus α-hemolysin channels in tethered bilayer lipid membranes, Biophys. J. 96 (2009), 1547 - 1553.
G. Valincius, F. Heinrich, R. Budvytyte, D. J. Vanderah, D. J. McGillivray, Y. Sokolov, J. E. Hall, and M. Lösche, Soluble amyloid β oligomers affect dielectric membrane properties by bilayer insertion and domain formation: Implications for cell toxicity, Biophys. J. 95 (2008), 4845 – 4861. / download BioFast preprint / download supplement
D. J. McGillivray, G. Valincius, D. J. Vanderah, W. Febo-Ayala, J. T. Woodward, F. Heinrich, J. J. Kasianowicz, and M. Lösche, Molecular-scale structural and functional characterization of sparsely tethered bilayer membranes, Biointerphases 2 (2007), 21 – 33. download paper / download supplement
J. Pittler, W. Bu, D. Vaknin, A. Travesset, D. J. McGillivray, and M. Lösche, Charge inversion at minute electrolyte concentrations, Phys. Rev. Lett. 97 (2006), 046102.
J. A. Dura, D. J. Pierce, C. F. Majkrzak, N. Maliszewskyj, D. J. McGillivray, M. Lösche, K. V. O’Donovan, M. Michailescu, U. A. Perez-Salas, D. L. Worcester, and S. H. White, AND/R: Advanced neutron diffractometer/reflectometer for investigation of thin films and multilayers for the life sciences, Rev. Sci. Instrum. 77 (2006), 074301.
Full list of publications
Short CV for Mathias Lösche